MF-438
| Overview | |
| Catalog # | bs-82920c-5-mg |
| Product Name | MF-438 |
| Specifications | |
| Storage Buffer | Pale yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models. |
| Description | CAS Number: 921605-87-0 Chemical Name: 2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole Molecular weight: 421.44 Formula: C19H18F3N5OS Solubility: Ethanol (2 mg/ml), DMSO (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Confirms) |
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