Harmine HCl

Overview
Catalog #	bs-82893c-25-mg
Product Name	Harmine HCl
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Selective competitive and reversible inhibitor of MAO-A (IC50 = 8 µM).1 Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM).2,3 Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation.4 Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5 Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6
Description	CAS Number: 343-27-1 Chemical Name: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride Molecular weight: 248.71 Formula: C13H12N2O·HCl Solubility: Water (25 mg/ml) Physical Properties: White solid Purity: >98% (TLC: 10% Methanol/methylene chloride + 0.5% NH4OH; Rf = 0.50)