PF-06840003
Overview | |
Catalog # | bs-82880c-10-mg |
Product Name | PF-06840003 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3 |
Description | CAS Number: 198474-05-4 Chemical Name: 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Molecular weight: 232.21 Formula: C12H9FN2O2 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms) |