IACS-010759

Overview
Catalog #	bs-82874c-5-mg
Product Name	IACS-010759
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	IACS-010759 (1570496-34-2) is a potent (IC50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I.2 Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death.3 It has also displayed potential in various chemotherapy-resistant cancer cell lines.4-7
Description	CAS Number: 1570496-34-2 Chemical Name: 5-[5-Methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxyphenyl]-1,2,4-oxadiazole Molecular weight: 562.57 Formula: C25H25F3N6O4S Solubility: DMSO (>25 mg/ml) Physical Properties: White to off-white solid Purity: >98% by HPLC NMR (Conforms)