Roxadustat

Overview
Catalog #	bs-82872c-5-mg
Product Name	Roxadustat
Specifications
Storage Buffer	Pale orange/yellow solid
Storage Condition	-20°C
Target
Product Information	Roxadustat (808118-40-3) is a pan-prolyl hydroxylase domain (PHD) inhibitor (IC50 for PHD2 = 591 nM)1 that stabilizes hypoxia-inducible factor (HIF) leading to erythropoiesis. Currently in clinical trials for treatment of anemia related to chronic kidney disease.2 Roxadustat accelerated cutaneous wound healing and shortened healing time via improvement in epidermal stem cell proliferation and motility3 and increasing angiogenesis4. It displayed radioprotective effects in haematopoietic systems via up-regulation of HIF-1.5 Roxadustat displayed protective effects against atherosclerosis via activation of adipose HIF-2.6
Description	CAS Number: 808118-40-3 Chemical Name: 2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid Molecular weight: 352.35 Formula: C19H16N2O5 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white or white solid Purity: 99% by HPLC