Icilin

Overview
Catalog #	bs-82851c-10-mg
Product Name	Icilin
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 µM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
Description	CAS Number: 36945-98-9 Chemical Name: 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one Molecular weight: 311.29 Formula: C16H13N3O4 Solubility: DMSO (25 mg/ml) Physical Properties: Yellow solid Purity: >98% by TLC [5% methanol in methylene chloride; Rf = 0.40]