Buparlisib

Overview
Catalog #	bs-82847c-5-mg
Product Name	Buparlisib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110ß = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1µM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
Description	CAS Number: 944396-07-0 Chemical Name: 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine Molecular weight: 410.39 Formula: C18H21F3N6O2 Solubility: DMSO (15 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms)