PF-4136309

Overview
Catalog #	bs-82835c-5-mg
Product Name	PF-4136309
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3
Description	CAS Number: 1341224-83-6 Chemical Name: N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide Molecular weight: 568.60 Formula: C29H31F3N6O3 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)