CGP-37157
| Overview | |
| Catalog # | bs-82832c-10-mg |
| Product Name | CGP-37157 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | RT |
| Target | |
| Product Information | Inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 μM.1 Does not inhibit the plasmalemmal NCX.2 Also inhibits voltage-gated Ca2+ channels in intact cells and therefore its use in cellular studies must employ adequate controls.3 Prevents sudden death in a Guinea pig model of heart failure.4 Displays pronounced cytoprotective effects in chromaffin cells5 and in neuronal injury models.6 Blood-brain barrier permeant. |
| Description | CAS Number: 75450-34-9 Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one Molecular weight: 324.22 Formula: C15H11Cl2NOS Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 99% by TLC |
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