BI01383298

Overview
Catalog #	bs-82817c-5-mg
Product Name	BI01383298
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	BI01383298 is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY).1,2 IC50 = 49 nM in the presence of Li+ with preincubation and 118 nM without Li+. BI01393298 is inactive in mouse NaCT for citrate transport. NaCT delivers citrate, a key metabolite and regulator of multiple biochemical pathways, from the blood to hepatocytes and neurons. Reduced expression of NaCT has been linked to longevity and increased expression has been linked to type 2 diabetes and non-alcoholic fatty liver disease. BI01383298 also blocked transport of arginine, dimethylarginine, and L-homoarginine in both human and mouse NaCT.2
Description	CAS Number: 2227549-00-8 Chemical Name: 1-(3,5-Dichlorophenylsulfonyl)-N-(4-fluorobenzyl)piperidine-4-carboxamide Molecular weight: 445.34 Formula: C19H19Cl2FN2O3S Solubility: DMSO (>35 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)