Belumosudil

Overview
Catalog #	bs-82812c-5-mg
Product Name	Belumosudil
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Selective inhibitor of Rho kinase 2 (ROCK2) – IC50’s: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays.1 It downregulated the ability of T cells to secrete IL-21 and IL-17, but not IFN-g, in response to T cell stimulation in vitro via a STAT3-dependent mechanism.2 Belumosudil ameliorated graft-versus-host disease in multiple models3,4 and was recently approved by the FDA for the treatment of GVHD (July 2021). It has also been shown to suppress adipogenesis.5-7 Suppression of adipocyte differentiation is mediated via casein kinase 2 inhibition (IC50 = 50 nM) and not ROCK2 inhibition.8
Description	CAS Number: 911417-87-3 Chemical Name: 2-[3-[4-(1H-Indazol-5-yl)amino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide Molecular weight: 452.52 Formula: C26H24N6O2 Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)