Alisertib
Overview | |
Catalog # | bs-82804c-5-mg |
Product Name | Alisertib |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway. |
Description | CAS Number: 1028486-01-2 Chemical Name: 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid Molecular weight: 518.92 Formula: C27H20ClFN4O4 Solubility: DMSO (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Conforms) |