LY2603618

Overview
Catalog #	bs-82803c-5-mg
Product Name	LY2603618
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	LY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response – combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
Description	CAS Number: 911222-45-2 Chemical Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea Molecular weight: 436.30 Formula: C18H22BrN5O3 Solubility: DMSO (>10 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Conforms)