BI 2536

Overview
Catalog #	bs-82801c-5-mg
Product Name	BI 2536
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	BI 2536 was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
Description	CAS Number: 755038-02-9 Chemical Name: 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Molecular weight: 521.67 Formula: C28H39N7O3 Solubility: DMSO (20 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Off-white solid Purity: 97% by HPLC, NMR (conforms)