UNC6934

Overview
Catalog #	bs-82799c-5-mg
Product Name	UNC6934
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	Potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2). It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2. UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases. Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 µM).
Description	CAS Number: 2561494-77-5 Chemical Name: N-Cyclopropyl-3-oxo-N-(4-pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide Molecular weight: 443.46 Formula: C24H21N5O4 Solubility: DMSO (>25 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMR (Conforms)