Galunisertib

Overview
Catalog #	bs-82796c-5-mg
Product Name	Galunisertib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Galunisertib is a TGF-B kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in clinical trials for treatment of various cancers.3-5 Galunisertib has more recently been used to enhance the anti-neuroblastoma activity of anti-GD2 antibody Dinutuximab with natural killer cells6 and preserved the function of in vitro expanded natural killer cells in AML and colon cancer models7. Galunisertib reversed TGF and regulatory T cell mediated suppression of human T cell proliferation. In combination with PD-L1 blockade, it resulted in improved tumor growth inhibition and complete regressions in colon carcinoma models.8
Description	CAS Number: 700874-72-2 Chemical Name: 4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide Molecular weight: 369.43 Formula: C22H19N5O Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98%, NMR (Conforms)