N6022

Overview
Catalog #	bs-82793c-5-mg
Product Name	N6022
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	N6022 is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50 = 20 nM1, 8 nM2. It demonstrated significant efficacy in a mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis) via selective inhibition of pro-inflammatory CD4+ cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+ cells (TH2/Treg) without causing lymphopenia.3
Description	CAS Number: 1208315-24-5 Chemical Name: 3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid Molecular weight: 414.46 Formula: C24H22N4O3 Solubility: DMSO >25 mg/ml Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)