Preladenant

Overview
Catalog #	bs-82792c-5-mg
Product Name	Preladenant
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	Preladenant is a potent (Ki = 1.1nM) and selective (>1000-fold over other adenosine receptors) adenosine A2A antagonist.1 It has shown efficacy in rodent and primate models of Parkinsons disease without inducing dyskinesias and displays antidepressant effects.1-3 It has been shown that activation of the adenosine A2A receptor blocks the activation of immune cells and increases the number of regulatory T-cells.4-6 Currently in clinical trials as combination therapy with pembrolizumab.7
Description	CAS Number: 377727-87-2 Chemical Name: 4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine Molecular weight: 503.57 Formula: C25H29N9O3 Solubility: DMSO (5 mg/ml with warming) Physical Properties: Beige solid Purity: >98% by HPLC NMR (Conforms)