CPI-444

Overview
Catalog #	bs-82791c-5-mg
Product Name	CPI-444
Specifications
Storage Buffer	Pale orange solid
Storage Condition	-20°C
Target
Product Information	CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3
Description	CAS Number: 1202402-40-1 Chemical Name: 7-(5-methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine Molecular weight: 407.43 Formula: C20H21N7O3 Solubility: DMSO (>25 mg/ml) Physical Properties: Beige solid Purity: 98% by HPLC NMR (Conforms)