PTC-209

Overview
Catalog #	bs-82764c-5-mg
Product Name	PTC-209
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8
Description	CAS Number: 315704-66-6 Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine Molecular weight: 495.19 Formula: C17H13Br2N5OS Solubility: DMSO (>25 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC , NMR (Conforms)