A-196

Overview
Catalog #	bs-82760c-5-mg
Product Name	A-196
Specifications
Storage Buffer	Off-white or beige solid
Storage Condition	-20°C
Target
Product Information	A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
Description	CAS Number: 1982372-88-2 Chemical Name: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine Molecular weight: 359.25 Formula: C18H16Cl2N4 Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)