URMC-099

Overview
Catalog #	bs-82755c-5-mg
Product Name	URMC-099
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid- degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
Description	CAS Number: 1229582-33-5 Chemical Name: 3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine Molecular weight: 421.54 Formula: C27H27N5 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)