KY-226

Overview
Catalog #	bs-82749c-5-mg
Product Name	KY-226
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	KY-226 (CAS 1621673-53-7) is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226’s anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4
Description	CAS Number: 1621673-53-7 Chemical Name: 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide Molecular weight: 481.67 Formula: C27H31NO3S2 Solubility: DMSO (>25 mg/mL) Physical Properties: Off-white solid Purity: >98% TLC