PF-05089771

Overview
Catalog #	bs-82745c-5-mg
Product Name	PF-05089771
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3 It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 µM for resting channels.1 Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2
Description	CAS Number: 1235403-62-9 Chemical Name: 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Molecular weight: 500.34 Formula: C18H12Cl2FN5O3S2 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)