Ceapin-A7

Overview
Catalog #	bs-82743c-10-mg
Product Name	Ceapin-A7
Specifications
Storage Buffer	Beige to pale orange solid
Storage Condition	-20°C
Target
Product Information	Selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6ß or SREBP or the IRE1 or PERK branches of the UPR. Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
Description	CAS Number: 2323027-38-7 Chemical Name: N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide Molecular weight: 470.33 Formula: C20H12F6N4O3 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC , NMR (Conforms)