Compound 147

Overview
Catalog #	bs-82742c-10-mg
Product Name	Compound 147
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2 AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3 It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
Description	CAS Number: 393121-74-9 Chemical Name: N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide Molecular weight: 255.32 Formula: C16H17NO2 Solubility: DMSO (>25 mg/ml); ethanol (>25 mg/mL) Physical Properties: Beige to pale orange solid Purity: 98% by HPLC , NMR (Conforms)