ML382

Overview
Catalog #	bs-82737c-10-mg
Product Name	ML382
Specifications
Storage Buffer	White to off-white solid
Storage Condition	-20°C
Target
Product Information	ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2
Description	CAS Number: 1646499-97-9 Chemical Name: 2-(Cyclopropanesulfonylamimo)-N-(2-ethoxyphenyl)benzamide Molecular weight: 360.43 Formula: C18H20N2O4S Solubility: DMSO (>25 mg/ml); ethanol (5 mg/mL with warming) Physical Properties: White solid Purity: 99% by HPLC NMR (Conforms)