SJ6986

Overview
Catalog #	bs-82734c-5-mg
Product Name	SJ6986
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
Description	CAS Number: 2765625-93-0 Chemical Name: N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide Molecular weight: 433.34 Formula: C20H14F3N3O5 Solubility: DMSO (>40 mg/ml) Physical Properties: White solid Purity: 98% by HPLC , NMR (Conforms)