Iberdomide

Overview
Catalog #	bs-82728c-5-mg
Product Name	Iberdomide
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
Description	CAS Number: 1323403-33-3 Chemical Name: (S)-3-(4-((4-(Morpholinometnyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione Molecular weight: 449.51 Formula: C25H27N3O5 Solubility: DMSO (50 mg/ml) Physical Properties: White solid Purity: >98% by HPLC , NMR (Conforms)