SI-2

Overview
Catalog #	bs-82720c-5-mg
Product Name	SI-2
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
Description	CAS Number: 380537-35-9 Chemical Name: 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine Molecular weight: 265.31 Formula: C15H15N5 Solubility: DMSO (20 mg/ml) Physical Properties: Pale orange solid Purity: 98% by HPLC NMR (Conforms)