Tigecycline

Overview
Catalog #	bs-82718c-10-mg
Product Name	Tigecycline
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Tigecycline is a clinically useful antibiotic.1,2 It is a glycylcycline derivative of minocycline that binds to the 30S ribosomal subunit of bacteria blocking the interaction of aminoacyl-tRNA with the ribosome. Tigecycline is active against Gram-positive and -negative bacteria, anaerobic bacteria and drug resistant bacteria such as MRSA, MRSE, and VRE. Tigecycline has also been shown to be selectively toxic to human acute myeloid leukemia cells over normal hematopoietic cells via inhibition of mitochondrial protein translation.3 It has also been found to be effective against other cancers including non-small cell lung cancer4, melanoma5, lymphoma6, and osteosarcoma7.
Description	CAS Number: 220620-09-7 Chemical Name: (4S,4aS,5aR,12aR)-9-[[2-(tert-Butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide Molecular weight: 585.66 Formula: C29H39N5O8 Solubility: DMSO (up to at least 25 mg/ml) Physical Properties: Orange solid Purity: 98% by HPLC NMR (Conforms)