EGA

Overview
Catalog #	bs-82702c-5-mg
Product Name	EGA
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	EGA is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1 Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
Description	CAS Number: 415687-81-9 Chemical Name: 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Molecular weight: 346.23 Formula: C16H16BrN3O Solubility: DMSO (50 mg/ml); Ethanol (10 mg/ml with warming) Physical Properties: White solid Purity: >95% by TLC NMR (Conforms)