NLRP3i

Overview
Catalog #	bs-82701c-20-mg
Product Name	NLRP3i
Specifications
Storage Buffer	Yellow solid
Storage Condition	RT
Target
Product Information	NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1 and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2
Description	CAS Number: 16673-34-0 Chemical Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide Molecular weight: 368.84 Formula: C16H17ClN2O4S Solubility: DMSO (45 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)