ABT-737

Overview
Catalog #	bs-82700c-5-mg
Product Name	ABT-737
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4
Description	CAS Number: 852808-04-9 Chemical Name: 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide Molecular weight: 813.43 Formula: C42H45ClN6O5S2 Solubility: DMSO (5 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms)