Streptonigrin

Overview
Catalog #	bs-82684c-1-mg
Product Name	Streptonigrin
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
Description	CAS Number: 3930-19-6 Chemical Name: Fermentation product from Streptomyces flocculus Molecular weight: 506.47 Formula: C25H22N4O8 Solubility: DMSO Physical Properties: Black solid Purity: >95% HPLC, NMR (Conforms)