RITA

Overview
Catalog #	bs-82671c-5-mg
Product Name	RITA
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 µM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
Description	CAS Number: 213261-59-7 Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol Molecular weight: 292.37 Formula: C14H12O3S2 Solubility: DMSO (20 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC NMr (Conforms)