Koningic acid

Overview
Catalog #	bs-82666c-1-mg
Product Name	Koningic acid
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 μM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5
Description	CAS Number: 74310-84-2 Chemical Name: (2’S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2’-oxirane]-4-carboxylic acid Molecular weight: 280.32 Formula: C15H20O5 Solubility: Water (1 mg/ml) Physical Properties: Off-white solid Purity: 95% by HPLC, NMR (Conforms)