2-AAPA
| Overview | |
| Catalog # | bs-82657c-5-mg |
| Product Name | 2-AAPA |
| Specifications | |
| Storage Buffer | Yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 µM respectively, and impairs mitochondrial function.1 May be used to induce a cellular model of thiol oxidative stress.2 Enhances sensitivity of cancer cell lines to X-ray irradiation.3 Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in α-tubulin S-glutathionylation-mediated microtubule depolymerization.4 Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1α.5 |
| Description | CAS Number: 1133387-90-2 Chemical Name: R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate Molecular weight: 518.65 Formula: C18H22N4O6S4 Solubility: DMSO (50 mg/ml) Physical Properties: White or off-white solid Purity: 98% by HPLC |
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