NSC59984

Overview
Catalog #	bs-82648c-5-mg
Product Name	NSC59984
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	p53 activator. Restores wild-type p53 signaling and depletes mutant p53 gain of function. Induces mutant p53 protein degradation via MDM2 and ubiquitin-proteasome pathway. Induces p73-dependent cell death in cancer cells without toxicity toward normal cells.1 Inhibition of p53-MDM2 interaction remains a viable strategy for cancer therapeutic development.2,3
Description	CAS Number: 803647-40-7 Chemical Name: (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one Molecular weight: 265.27 Formula: C12H15N3O4 Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)