Tolcapone

Overview
Catalog #	bs-82642c-10-mg
Product Name	Tolcapone
Specifications
Storage Buffer	Light yellow solid
Storage Condition	-20°C
Target
Product Information	Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable
Description	CAS Number: 134308-13-7 Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone Molecular weight: 273.24 Formula: C14H11NO5 Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)