MDL-28170

Overview
Catalog #	bs-82628c-5-mg
Product Name	MDL-28170
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 µM in intact cell assay.4
Description	CAS Number: 88191-84-8 Chemical Name: N-Benzyloxycarbonylvalylphenylalaninal Molecular weight: 382.45 Formula: C22H26N2O4 Solubility: DMSO (75 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)