Emetine hydrochloride

Overview
Catalog #	bs-82627c-50-mg
Product Name	Emetine hydrochloride
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	One of the active ingredients of ipecac root extract, used as an emetic.1 Induces apoptosis in breast cancer cells via inhibition of Wnt/-catenin signaling.2 Inhibits Zika and Ebola virus in vitro and in vivo, targeting viral entry and replication by inhibiting viral RNA polymerase and host lysosomal function.3 Also inhibits SARS-CoV-2 replication in cells (EC50 for viral load reduction is 0.46 M).4 A useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit.5
Description	CAS Number: 483-18-1 Chemical Name: (2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine, dihydrochloride, hydrate Molecular weight: 553.56 Formula: C29H40N2O4 ∙ 2HCl (XH2O) Solubility: Water (100 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)