CX-5461

Overview
Catalog #	bs-82626c-5-mg
Product Name	CX-5461
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5
Description	CAS Number: 1138549-36-6 Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo [3,2-a][1,8]naphthyridine-6-carboxamide Molecular weight: 513.62 Formula: C27H27N7O2S Solubility: DMSO (10 mg/ml with warming) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (Conforms)