PAC-1

Overview
Catalog #	bs-82621c-5-mg
Product Name	PAC-1
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2 Sensitizes cancer cells to various chemotherapeutic agents.3
Description	CAS Number: 315183-21-2 Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]-methylene]hydrazide Molecular weight: 392.49 Formula: C23H28N4O2 Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Conforms)