PLX-4032

Overview
Catalog #	bs-82612c-5-mg
Product Name	PLX-4032
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4
Description	CAS Number: 918504-65-1 Chemical Name: N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide Molecular weight: 489.92 Formula: C23H18ClF2N3O3S Solubility: DMSO (100 mg/ml) Physical Properties: White or off-white solid Purity: 99% by HPLC, NMR (Conforms)