SB-225002

Overview
Catalog #	bs-82596c-5-mg
Product Name	SB-225002
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors.1 Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe.2 Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence3 and neutrophil chemotaxis1. Inhibits HIV replication in lymphocytes and macrophages.4 Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation.5
Description	CAS Number: 182498-32-4 Chemical Name: N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea Molecular weight: 352.14 Formula: C13H10BrN3O4 Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms)