Pomalidomide

Overview
Catalog #	bs-82578c-20-mg
Product Name	Pomalidomide
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
Description	CAS Number: 19171-19-8 Chemical Name: 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide Molecular weight: 273.24 Formula: C13H11N3O4 Solubility: DMSO (50 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)