NSC23766

Overview
Catalog #	bs-82568c-5-mg
Product Name	NSC23766
Specifications
Storage Buffer	White or off-white solid
Storage Condition	RT
Target
Product Information	NSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
Description	CAS Number: 733767-34-5 Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrocholoride Molecular weight: 530.98 Formula: C24H35N7 · 3HCl Solubility: DMSO (50 mg/ml) Water (50 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)