Probucol
Overview | |
Catalog # | bs-82555c-1-g |
Product Name | Probucol |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | RT |
Target | |
Product Information | Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6 |
Description | CAS Number: 23288-49-5 Chemical Name: 4,4’-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol Molecular weight: 516.84 Formula: C31H48O2S2 Solubility: DMSO (100 mg/ml) Ethanol (50 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC / TLC NMR (Conforms) |