DMXAA

Overview
Catalog #	bs-82554c-5-mg
Product Name	DMXAA
Specifications
Storage Buffer	White or off-white solid
Storage Condition	RT
Target
Product Information	STING (Stimulator of Interferon Genes) agonist selective for mouse STING.1,2 Intratumoral administration of DMXAA resulted in tumor regression and complete rejection in mouse xenografts.3 Tumor regression induced by DMXAA results from a cascade of cellular events which include disruption of tumor vasculature followed by the release of chemokines which trigger the recruitment of immune cells.4 DMXAA induced expression of IFN- resulting in a striking expansion of leukemia-specific T cells extending survival in two acute myeloid leukemia models.5
Description	CAS Number: 117570-53-3 Chemical Name: 5,6-Dimethylxanthenone-4-acetic acid Molecular weight: 282.29 Formula: C17H14O4 Solubility: DMSO (5 mg/ml) DMF (14 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)